The chemical biology of IL-12 productionviathe non-canonical NFkB pathway
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چکیده
منابع مشابه
IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells
The canonical pathway for IL-1β production requires TLR-mediated NF-κB-dependent Il1b gene induction, followed by caspase-containing inflammasome-mediated processing of pro-IL-1β. Here we show that IL-21 unexpectedly induces IL-1β production in conventional dendritic cells (cDCs) via a STAT3-dependent but NF-κB-independent pathway. IL-21 does not induce Il1b expression in CD4(+) T cells, with d...
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چکیده ندارد.
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ژورنال
عنوان ژورنال: RSC Chemical Biology
سال: 2020
ISSN: 2633-0679
DOI: 10.1039/d0cb00022a